Selected Publications from Tan-Yang Center Labs

Revealing the structure of pharmacobehavioral space through motion sequencing. Wiltschko AB, Tsukahara T, Zeine A, Anyoha R, Gillis WF, Markowitz JE, Peterson RE, Katon J, Johnson MJ, Datta SR. Nat Neurosci. 2020 Nov;23(11):1433-1443.

Parallel ascending spinal pathways for affective touch and pain. Choi S, Hachisuka J, Brett MA, Magee AR, Omori Y, Iqbal NU, Zhang D, DeLisle MM, Wolfson RL, Bai L, Santiago C, Gong S, Goulding M, Heintz N, Koerber HR, Ross SE, Ginty DD. Nature. 2020 Oct 28

Homozygous deletions implicate non-coding epigenetic marks in Autism spectrum disorder.
Schmitz-Abe K, Sanchez-Schmitz G, Doan RN, Hill RS, Chahrour MH, Mehta BK, Servattalab S, Ataman B, Lam AN, Morrow EM, Greenberg ME, Yu TW, Walsh CA, Markianos K. Sci Rep. 2020 Aug 20

Large-Scale Exome Sequencing Study Implicates Both Developmental and Functional Changes in the Neurobiology of Autism. Satterstrom FK, Kosmicki JA, Wang J, Breen MS, De Rubeis S, An JY, Peng M, Collins R, Grove J, Klei L, Stevens C, Reichert J, Mulhern MS, Artomov M, Gerges S, Sheppard B, Xu X, Bhaduri A, Norman U, Brand H, Schwartz G, Nguyen R, Guerrero EE, Dias C; Autism Sequencing Consortium; iPSYCH-Broad Consortium, Betancur C, Cook EH, Gallagher L, Gill M, Sutcliffe JS, Thurm A, Zwick ME, Børglum AD, State MW, Cicek AE, Talkowski ME, Cutler DJ, Devlin B, Sanders SJ, Roeder K, Daly MJ, Buxbaum JD. Cell. 2020 Feb 6.

Peripheral Somatosensory Neuron Dysfunction: Emerging Roles in Autism Spectrum Disorders. Orefice LL. Neuroscience. 2020 Feb 6.

Targeting Peripheral Somatosensory Neurons to Improve Tactile-Related Phenotypes in ASD Models. Orefice LL, Mosko JR, Morency DT, Wells MF, Tasnim A, Mozeika SM, Ye M, Chirila AM, Emanuel AJ, Rankin G, Fame RM, Lehtinen MK, Feng G, Ginty DD. Cell. 2019 Aug 8.

HMS News Feature:
Decoding Touch: New research points to potential therapy for abnormal touch sensitivity in autism spectrum disorders

Deep learning of spontaneous arousal fluctuations detects early cholinergic defects across neurodevelopmental mouse models and patients. Artoni P, Piffer A, Vinci V, LeBlanc J, Nelson CA, Hensch TK, Fagiolini M. Proc Natl Acad Sci U S A. 2019 Jul 22.

Molecular, spatial, and functional single-cell profiling of the hypothalamic preoptic region. Moffitt JR, Bambah-Mukku D, Eichhorn SW, Vaughn E, Shekhar K, Perez JD, Rubinstein ND, Hao J, Regev A, Dulac C, Zhuang X. Science. 2018 Nov 16.

Harvard Gazette Feature:
Cellular atlas of brain region leads to discoveries

Activity-Regulated Transcription: Bridging the Gap between Neural Activity and Behavior. Yap EL, Greenberg ME. Neuron. 2018 Oct 24.

Visual Experience-Dependent Expression of Fn14 Is Required for Retinogeniculate Refinement. Cheadle L, Tzeng CP, Kalish BT, Harmin DA, Rivera S, Ling E, Nagy MA, Hrvatin S, Hu L, Stroud H, Burkly LC, Chen C, Greenberg ME. Neuron. 2018 Aug 8.

HMS News Feature:
Sensory Refinement: A key protein helps the brain remodel itself in response to sensory experiences

AP-1 Transcription Factors and the BAF Complex Mediate Signal-Dependent Enhancer Selection. Vierbuchen T, Ling E, Cowley CJ, Couch CH, Wang X, Harmin DA, Roberts CWM, Greenberg ME. Mol Cell. 2017 Dec 21.

Rates, distribution and implications of postzygotic mosaic mutations in autism spectrum disorder. Lim ET, Uddin M, De Rubeis S, Chan Y, Kamumbu AS, Zhang X, D'Gama AM, Kim SN, Hill RS, Goldberg AP, Poultney C, Minshew NJ, Kushima I, Aleksic B, Ozaki N, Parellada M, Arango C, Penzol MJ, Carracedo A, Kolevzon A, Hultman CM, Weiss LA, Fromer M, Chiocchetti AG, Freitag CM; Autism Sequencing Consortium, Church GM, Scherer SW, Buxbaum JD, Walsh CA. Nat Neurosci. 2017 Sept.

HMS News Feature:
Late in the Game: Post-conception mutations may play an important role in autism

Mutations in Human Accelerated Regions Disrupt Cognition and Social Behavior. Doan RN, Bae BI, Cubelos B, Chang C, Hossain AA, Al-Saad S, Mukaddes NM, Oner O, Al-Saffar M, Balkhy S, Gascon GG; Homozygosity Mapping Consortium for Autism, Nieto M, Walsh CA. Cell. 2016 Oct 6.

HMS News Feature:
Autism and Evolution: Genomic regions that set humans apart from other primates carry many autism-linked mutations

Peripheral Mechanosensory Neuron Dysfunction Underlies Tactile and Behavioral Deficits in Mouse Models of ASDs. Orefice LL, Zimmerman AL, Chirila AM, Sleboda SJ, Head JP, Ginty DD. Cell. 2016 Jul 14.

HMS News Feature:
Autism's Reach: Mouse study suggests autism is not just a disorder of the brain

Mapping Sub-Second Structure in Mouse Behavior. Wiltschko AB, Johnson MJ, Iurilli G, Peterson RE, Katon JM, Pashkovski SL, Abraira VE, Adams RP, Datta SR. Neuron. 2015 Dec 16.

Related Harvard Magazine 2018 article on MoSeq technique: A language of behavior?

Related BMC Biology 2019 article:
Q&A: Understanding the composition of behavior. Datta SR. BMC Biol. 2019 May 29.

Autism: a "critical period" disorder? LeBlanc JJ, Fagiolini M. Neural Plast. 2011.